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PROSITE documentation PDOC00423 |
Aconitase (aconitate hydratase) (EC 4.2.1.3) [1] is the enzyme from the tricarboxylic acid cycle that catalyzes the reversible isomerization of citrate and isocitrate. Cis-aconitate is formed as an intermediary product during the course of the reaction. In eukaryotes two isozymes of aconitase are known to exist: one found in the mitochondrial matrix and the other found in the cytoplasm. Aconitase, in its active form, contains a 4Fe-4S iron-sulfur cluster; three cysteine residues have been shown to be ligands of the 4Fe-4S cluster.
It has been shown that the aconitase family also contains the following proteins:
As a signature for proteins from the aconitase family we have selected two conserved regions that contain the three cysteine ligands of the 4Fe-4S cluster.
Last update:December 2004 / Pattern and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Gruer M.J. Artymiuk P.J. Guest J.R. |
Title | The aconitase family: three structural variations on a common theme. | |
Source | Trends Biochem. Sci. 22:3-6(1997). | |
PubMed ID | 9020582 |