PROSITE documentation PDOC00429
Sodium:solute symporter family signatures and profile


It has been shown [1,2] that integral membrane proteins that mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. One of these families is known as the sodium:solute symporter family (SSF) and currently consists of the following proteins:

  • Mammalian Na+/glucose co-transporter.
  • Mammalian Na+/myo-inositol co-transporter.
  • Mammalian Na+/nucleoside co-transporter.
  • Mammalian Na+/neutral amino acid co-transporter.
  • Mammalian Na+/iodide co-transporter.
  • Mammalian Na+/multivitamin co-transporter.
  • Escherichia coli Na+/proline symporter (gene putP).
  • Escherichia coli Na+/pantothenate symporter (gene panF).
  • Escherichia coli hypothetical protein yidK.
  • Escherichia coli hypothetical protein yjcG.
  • Bacillus subtilis hypothetical protein ywcA (ipa-31R).

These integral membrane proteins are predicted to comprise at least ten membrane spanning domains. As signature patterns we selected two conserved regions; the first one is located in the fourth transmembrane region and the second one in a loop between two transmembrane regions in the C-terminal part of these proteins.

Last update:

December 2001 / Patterns and text revised; profile added.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

NA_SOLUT_SYMP_3, PS50283; Sodium:solute symporter family profile  (MATRIX)

NA_SOLUT_SYMP_1, PS00456; Sodium:solute symporter family signature 1  (PATTERN)

NA_SOLUT_SYMP_2, PS00457; Sodium:solute symporter family signature 2  (PATTERN)


1AuthorsReizer J. Reizer A. Saier M.H. Jr.
TitleThe Na+/pantothenate symporter (PanF) of Escherichia coli is homologous to the Na+/proline symporter (PutP) of E. coli and the Na+/glucose symporters of mammals.
SourceRes. Microbiol. 141:1069-1072(1990).
PubMed ID1965458

2AuthorsReizer J. Reizer A. Saier M.H. Jr.
TitleA functional superfamily of sodium/solute symporters.
SourceBiochim. Biophys. Acta 1197:133-166(1994).
PubMed ID8031825

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