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PROSITE documentation PDOC00441Malate synthase signature
Description
Malate synthase (EC 2.3.3.9) catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate - the second step of the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants.
Malate synthase is a protein of 530 to 570 amino acids whose sequence is highly conserved across species [1]. As a signature pattern, we selected a very conserved region in the central section of the enzyme.
Last update:December 2004 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Bruinenberg P.G. Blaauw M. Kazemier B. Ab G. |
| Title | Cloning and sequencing of the malate synthase gene from Hansenula polymorpha. | |
| Source | Yeast 6:245-254(1990). | |
| PubMed ID | 2349836 |
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