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PROSITE documentation PDOC00441

Malate synthase signature


Malate synthase (EC catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate - the second step of the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants.

Malate synthase is a protein of 530 to 570 amino acids whose sequence is highly conserved across species [1]. As a signature pattern, we selected a very conserved region in the central section of the enzyme.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

MALATE_SYNTHASE, PS00510; Malate synthase signature  (PATTERN)


1AuthorsBruinenberg P.G., Blaauw M., Kazemier B., Ab G.
TitleCloning and sequencing of the malate synthase gene from Hansenula polymorpha.
SourceYeast 6:245-254(1990).
PubMed ID2349836

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