We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00441Malate synthase signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00441
Description
Malate synthase (EC 2.3.3.9) catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate - the second step of the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants.
Malate synthase is a protein of 530 to 570 amino acids whose sequence is highly conserved across species [1]. As a signature pattern, we selected a very conserved region in the central section of the enzyme.
Last update:December 2004 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Bruinenberg P.G. Blaauw M. Kazemier B. Ab G. |
| Title | Cloning and sequencing of the malate synthase gene from Hansenula polymorpha. | |
| Source | Yeast 6:245-254(1990). | |
| PubMed ID | 2349836 |
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