PROSITE documentation PDOC00490Phosphoribulokinase signature
Phosphoribulokinase (EC 2.7.1.19) (PRK) [1,2] is one of the enzymes specific to the Calvin's reductive pentose phosphate cycle which is the major route by which carbon dioxide is assimilated and reduced by autotrophic organisms. PRK catalyzes the ATP-dependent phosphorylation of ribulose 5-phosphate into ribulose 1,5-bisphosphate which is the substrate for RubisCO.
PRK's of diverse origins show different properties with respect to the size of the protein, the subunit structure, or the enzymatic regulation. However an alignment of the sequences of PRK from plants, algae, photosynthetic and chemoautotrophic bacteria shows that there are a few regions of sequence similarity. As a signature pattern we have selected one of these regions.
Last update:December 1991 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Kossmann J. Klintworth R. Bowien B. |
| Title | Sequence analysis of the chromosomal and plasmid genes encoding phosphoribulokinase from Alcaligenes eutrophus. | |
| Source | Gene 85:247-252(1989). | |
| PubMed ID | 2559876 |
| 2 | Authors | Gibson J.L. Chen J.-H. Tower P.A. Tabita F.R. |
| Title | The form II fructose 1,6-bisphosphatase and phosphoribulokinase genes form part of a large operon in Rhodobacter sphaeroides: primary structure and insertional mutagenesis analysis. | |
| Source | Biochemistry 29:8085-8093(1990). | |
| PubMed ID | 2175647 |
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