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PROSITE documentation PDOC00490

Phosphoribulokinase signature





Description

Phosphoribulokinase (EC 2.7.1.19) (PRK) [1,2] is one of the enzymes specific to the Calvin's reductive pentose phosphate cycle which is the major route by which carbon dioxide is assimilated and reduced by autotrophic organisms. PRK catalyzes the ATP-dependent phosphorylation of ribulose 5-phosphate into ribulose 1,5-bisphosphate which is the substrate for RubisCO.

PRK's of diverse origins show different properties with respect to the size of the protein, the subunit structure, or the enzymatic regulation. However an alignment of the sequences of PRK from plants, algae, photosynthetic and chemoautotrophic bacteria shows that there are a few regions of sequence similarity. As a signature pattern we have selected one of these regions.

Last update:

December 1991 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

PHOSPHORIBULOKINASE, PS00567; Phosphoribulokinase signature  (PATTERN)


References

1AuthorsKossmann J. Klintworth R. Bowien B.
TitleSequence analysis of the chromosomal and plasmid genes encoding phosphoribulokinase from Alcaligenes eutrophus.
SourceGene 85:247-252(1989).
PubMed ID2559876

2AuthorsGibson J.L. Chen J.-H. Tower P.A. Tabita F.R.
TitleThe form II fructose 1,6-bisphosphatase and phosphoribulokinase genes form part of a large operon in Rhodobacter sphaeroides: primary structure and insertional mutagenesis analysis.
SourceBiochemistry 29:8085-8093(1990).
PubMed ID2175647



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