PROSITE documentation PDOC00491Myelin P0 protein signature
The P0 protein is a major structural glycoprotein of the peripheral nervous system (PNS) myelin which probably plays an important role for the formation and the maintenance of myelin structure [1,2,3].
P0 is a protein of about 28 Kd that consists of three domains: a N-terminal extracellular domain of about 125 residues which seems to form a V-type immunoglobulin domain; a transmembrane region, and a cytoplasmic C-terminal domain of about 70 residues which contains many positively charged residues and which is a substrate of some serine protein kinases.
P0 is well conserved across species. As a signature pattern we selected a region located in the C-terminal part of the cytoplasmic domain that contains many positive charges and serine residues that could be phosphorylated.
Last update:November 1997 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Filbin M.T. Tennekoon G.I. |
| Title | Myelin P0-protein, more than just a structural protein? | |
| Source | BioEssays 14:541-547(1992). | |
| PubMed ID | 1285424 |
| 2 | Authors | Uyemura K. Kitamura K. |
| Source | Comp. Biochem. Physiol. 98C:63-72(1991). |
| 3 | Authors | Inouye H. Kirschner D.A. |
| Title | Folding and function of the myelin proteins from primary sequence data. | |
| Source | J. Neurosci. Res. 28:1-17(1991). | |
| PubMed ID | 1710279 |
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