PROSITE documentation PDOC00491
Myelin P0 protein signature


The P0 protein is a major structural glycoprotein of the peripheral nervous system (PNS) myelin which probably plays an important role for the formation and the maintenance of myelin structure [1,2,3].

P0 is a protein of about 28 Kd that consists of three domains: a N-terminal extracellular domain of about 125 residues which seems to form a V-type immunoglobulin domain; a transmembrane region, and a cytoplasmic C-terminal domain of about 70 residues which contains many positively charged residues and which is a substrate of some serine protein kinases.

P0 is well conserved across species. As a signature pattern we selected a region located in the C-terminal part of the cytoplasmic domain that contains many positive charges and serine residues that could be phosphorylated.

Last update:

November 1997 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

MYELIN_P0, PS00568; Myelin P0 protein signature  (PATTERN)


1AuthorsFilbin M.T. Tennekoon G.I.
TitleMyelin P0-protein, more than just a structural protein?
SourceBioEssays 14:541-547(1992).
PubMed ID1285424

2AuthorsUyemura K. Kitamura K.
SourceComp. Biochem. Physiol. 98C:63-72(1991).

3AuthorsInouye H. Kirschner D.A.
TitleFolding and function of the myelin proteins from primary sequence data.
SourceJ. Neurosci. Res. 28:1-17(1991).
PubMed ID1710279

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