PROSITE documentation PDOC00492
Myelin basic protein signature


Myelin basic protein (MBP) [1,2] is an important hydrophilic protein which may function to maintain proper structure of myelin. MBP interacts with myelin lipids both electrostatically and by hydrophobic interactions.

In mammals various forms of MBP exist which are produced by the alternative splicing of a single gene; these forms differ by the presence or the absence of short (10 to 20 residues) peptides in various internal locations in the sequence. The major form of MBP is generally a protein of about 18.5 Kd (170 residues).

MBP is the target of many post-translational modifications: it is N-terminally acetylated, methylated on an arginine residue, phosphorylated by various serine/threonine protein-kinases, and deamidated on some glutamine residues.

As a signature pattern for MBP we selected the best conserved part of the protein, a perfectly conserved heptapeptide.

Last update:

December 1991 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

MYELIN_MBP, PS00569; Myelin basic protein signature  (PATTERN)


1AuthorsDeber C.M. Reynolds S.J.
TitleCentral nervous system myelin: structure, function, and pathology.
SourceClin. Biochem. 24:113-134(1991).
PubMed ID1710177

2AuthorsInouye H. Kirschner D.A.
TitleFolding and function of the myelin proteins from primary sequence data.
SourceJ. Neurosci. Res. 28:1-17(1991).
PubMed ID1710279

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)