PROSITE documentation PDOC00513
Aromatic amino acids permeases signature


It has been shown [1] that some proteins involved in the transport of aromatic amino acids in Escherichia coli and related bacteria are evolutionary related; these permeases are:

  • Tryptophan-specific transport protein (tryptophan permease) (gene mtr).
  • Low affinity tryptophan permease (gene tnaB or trpP).
  • Tyrosine-specific transport protein (tyrosine permease) (gene tyrP).
  • Tyrosine permease from Erwinia herbicola (gene: tutB).

These permeases are proteins of about 400 to 420 amino acids which probably contain 11 or 12 transmembrane regions. The best conserved domain is a stretch of 20 residues which seems to be located in a cytoplasmic loop between the first and second transmembrane region.

Last update:

November 1997 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

AROMATIC_AA_PERMEASE_1, PS00594; Aromatic amino acids permeases signature  (PATTERN)


1AuthorsSarsero J.P. Wookey P.J. Gollnick P. Yanofsky C. Pittard A.J.
TitleA new family of integral membrane proteins involved in transport of aromatic amino acids in Escherichia coli.
SourceJ. Bacteriol. 173:3231-3234(1991).
PubMed ID2022620

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