PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE documentation PDOC00513
Aromatic amino acids permeases signature


View entry in original PROSITE document format
View entry in raw text format (no links)
PURL: https://purl.expasy.org/prosite/documentation/PDOC00513

Description

It has been shown [1] that some proteins involved in the transport of aromatic amino acids in Escherichia coli and related bacteria are evolutionary related; these permeases are:

  • Tryptophan-specific transport protein (tryptophan permease) (gene mtr).
  • Low affinity tryptophan permease (gene tnaB or trpP).
  • Tyrosine-specific transport protein (tyrosine permease) (gene tyrP).
  • Tyrosine permease from Erwinia herbicola (gene: tutB).

These permeases are proteins of about 400 to 420 amino acids which probably contain 11 or 12 transmembrane regions. The best conserved domain is a stretch of 20 residues which seems to be located in a cytoplasmic loop between the first and second transmembrane region.

Last update:

November 1997 / Pattern and text revised.

-------------------------------------------------------------------------------


Technical section

PROSITE method (with tools and information) covered by this documentation:

AROMATIC_AA_PERMEASE_1, PS00594; Aromatic amino acids permeases signature  (PATTERN)


Reference

1AuthorsSarsero J.P. Wookey P.J. Gollnick P. Yanofsky C. Pittard A.J.
TitleA new family of integral membrane proteins involved in transport of aromatic amino acids in Escherichia coli.
SourceJ. Bacteriol. 173:3231-3234(1991).
PubMed ID2022620



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.