We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00530cAMP phosphodiesterases class-II signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00530
Description
Cyclic AMP phosphodiesterase (EC 3.1.4.17) (cAMP-PDEase) catalyzes the hydrolysis of cAMP to the corresponding nucleoside 5' monophosphate. While most PDEases can be, on the basis of sequence similarities, grouped together [1], there are at least two enzymes which do not belong to the main family of PDEases and which represent a second class of these enzymes [2]:
- Slime mold Dictyostelium discoideum extracellular cAMP PDEase. This enzyme plays an essential role in development by hydrolyzing the cAMP used as a chemoattractant by aggregating cells.
- Budding yeast and Candida albicans low-affinity cAMP PDEase (gene PDE1).
- Fission yeast probable cAMP PDEase (gene cgs2).
- Vibrio fischeri periplasmic cAMP PDEase (gene cpdP) [3].
There is, in the central part of these enzymes, a highly conserved region which contains three histidines. We have used this region as a signature pattern.
Last update:December 2001 / Text revised.
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Technical section
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References
| 1 | Authors | Beavo J.A. Reifsnyder D.H. |
| Title | Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. | |
| Source | Trends Pharmacol. Sci. 11:150-155(1990). | |
| PubMed ID | 2159198 |
| 2 | Authors | Nikawa J.-I. Sass P. Wigler M. |
| Title | Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. | |
| Source | Mol. Cell. Biol. 7:3629-3636(1987). | |
| PubMed ID | 2824992 |
| 3 | Authors | Dunlap P.V. Callahan S.M. |
| Title | Characterization of a periplasmic 3':5'-cyclic nucleotide phosphodiesterase gene, cpdP, from the marine symbiotic bacterium Vibrio fischeri. | |
| Source | J. Bacteriol. 175:4615-4624(1993). | |
| PubMed ID | 8393003 |
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