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PROSITE documentation PDOC00540 |
The following extracellular heparin-binding proteins involved in regulation of growth and differentiation belong to a new family of growth factors:
These growth factors are highly related proteins of about 140 amino acids that contain 10 conserved cysteines probably involved in disulfide bonds (their position is schematically represented in the figure below). These proteins are also rich in basic residues and in tryptophan.
xxxxxxxCxxxCxxxCxxxxxCxxxCxCxxxxCxxxxCxxxxxxxxxxCxxxxCxxxxxxxxxxxxx ************* *************
'C': conserved cysteine probably involved in a disulfide bond. '*': position of the patterns.
We developed two signature patterns for this family of growth factors. As shown in the figure above, the patterns include the majority of the conserved cysteines.
Last update:May 2004 / Text revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Li Y.-S. Milner P.G. Chauhan A.K. Watson M.A. Hoffman R.M. Kodner C.M. Milbrandt J. Deuel T.F. |
Source | Science 250:1690-1693(1990). |
2 | Authors | Tsutsui J.-I. Uehara K. Kadomatsu K. Matsubara S. Muramatsu T. |
Title | A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse. | |
Source | Biochem. Biophys. Res. Commun. 176:792-797(1991). | |
PubMed ID | 2025291 |
3 | Authors | Urios P. Duprez D. Le Caer J.-P. Courtois Y. Vigny M. Laurent M. |
Title | Molecular cloning of RI-HB, a heparin binding protein regulated by retinoic acid. | |
Source | Biochem. Biophys. Res. Commun. 175:617-624(1991). | |
PubMed ID | 2018506 |
4 | Authors | Tsujimura A. Yasojima K. Kuboki Y. Suzuki A. Ueno N. Shiokawa K. Hashimoto-Gotoh T. |
Title | Developmental and differential regulations in gene expression of Xenopus pleiotrophic factors-alpha and -beta. | |
Source | Biochem. Biophys. Res. Commun. 214:432-439(1995). | |
PubMed ID | 7677748 |