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PROSITE documentation PDOC00547 |
It has been shown [1] that several proteins share two sequence motifs. Two of these proteins are enzymes of the inositol phosphate second messenger signalling pathway:
The function of the other proteins is not yet clear:
It is suggested [1] that these proteins may act by enhancing the synthesis or degradation of phosphorylated messenger molecules. From the X-ray structure of human inositol monophosphatase [3], it seems that some of the conserved residues are involved in binding a metal ion and/or the phosphate group of the substrate.
Last update:April 2006 / Pattern revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Neuwald A.F. York J.D. Majerus P.W. |
Title | Diverse proteins homologous to inositol monophosphatase. | |
Source | FEBS Lett. 294:16-18(1991). | |
PubMed ID | 1660408 |
2 | Authors | Glaeser H.-U. Thomas D. Gaxiola R. Montrichard F. Surdin-Kerjan Y. Serrano R. |
Source | EMBO J. 12:3105-3110(1993). |
3 | Authors | Bone R. Springer J.P. Atack J.R. |
Title | Structure of inositol monophosphatase, the putative target of lithium therapy. | |
Source | Proc. Natl. Acad. Sci. U.S.A. 89:10031-10035(1992). | |
PubMed ID | 1332026 |