PROSITE documentation PDOC00547Inositol monophosphatase family signatures
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00547
Description
It has been shown [1] that several proteins share two sequence motifs. Two of these proteins are enzymes of the inositol phosphate second messenger signalling pathway:
- Vertebrate, plants and microbial myo-inositol monophosphatase (EC 3.1.3.25).
- Vertebrate inositol polyphosphate 1-phosphatase (EC 3.1.3.57).
The function of the other proteins is not yet clear:
- Bacterial protein cysQ. CysQ could help to control the pool of PAPS (3'-phosphoadenoside 5'-phosphosulfate), or be useful in sulfite synthesis.
- Neurospora crassa protein Qa-X. Probably involved in quinate metabolism.
- Emericella nidulans protein qutG. Probably involved in quinate metabolism.
- Yeast protein HAL2/MET22 [2] involved in salt tolerance as well as methionine biosynthesis.
- Yeast hypothetical hypothetical protein YHR046c.
- Caenorhabditis elegans hypothetical protein F13G3.5.
It is suggested [1] that these proteins may act by enhancing the synthesis or degradation of phosphorylated messenger molecules. From the X-ray structure of human inositol monophosphatase [3], it seems that some of the conserved residues are involved in binding a metal ion and/or the phosphate group of the substrate.
Last update:April 2006 / Pattern revised.
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Technical section
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References
| 1 | Authors | Neuwald A.F. York J.D. Majerus P.W. |
| Title | Diverse proteins homologous to inositol monophosphatase. | |
| Source | FEBS Lett. 294:16-18(1991). | |
| PubMed ID | 1660408 |
| 2 | Authors | Glaeser H.-U. Thomas D. Gaxiola R. Montrichard F. Surdin-Kerjan Y. Serrano R. |
| Source | EMBO J. 12:3105-3110(1993). |
| 3 | Authors | Bone R. Springer J.P. Atack J.R. |
| Title | Structure of inositol monophosphatase, the putative target of lithium therapy. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:10031-10035(1992). | |
| PubMed ID | 1332026 |
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