We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00547Inositol monophosphatase family signatures
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00547
Description
It has been shown [1] that several proteins share two sequence motifs. Two of these proteins are enzymes of the inositol phosphate second messenger signalling pathway:
- Vertebrate, plants and microbial myo-inositol monophosphatase (EC 3.1.3.25).
- Vertebrate inositol polyphosphate 1-phosphatase (EC 3.1.3.57).
The function of the other proteins is not yet clear:
- Bacterial protein cysQ. CysQ could help to control the pool of PAPS (3'-phosphoadenoside 5'-phosphosulfate), or be useful in sulfite synthesis.
- Neurospora crassa protein Qa-X. Probably involved in quinate metabolism.
- Emericella nidulans protein qutG. Probably involved in quinate metabolism.
- Yeast protein HAL2/MET22 [2] involved in salt tolerance as well as methionine biosynthesis.
- Yeast hypothetical hypothetical protein YHR046c.
- Caenorhabditis elegans hypothetical protein F13G3.5.
It is suggested [1] that these proteins may act by enhancing the synthesis or degradation of phosphorylated messenger molecules. From the X-ray structure of human inositol monophosphatase [3], it seems that some of the conserved residues are involved in binding a metal ion and/or the phosphate group of the substrate.
Last update:April 2006 / Pattern revised.
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Technical section
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References
| 1 | Authors | Neuwald A.F. York J.D. Majerus P.W. |
| Title | Diverse proteins homologous to inositol monophosphatase. | |
| Source | FEBS Lett. 294:16-18(1991). | |
| PubMed ID | 1660408 |
| 2 | Authors | Glaeser H.-U. Thomas D. Gaxiola R. Montrichard F. Surdin-Kerjan Y. Serrano R. |
| Source | EMBO J. 12:3105-3110(1993). |
| 3 | Authors | Bone R. Springer J.P. Atack J.R. |
| Title | Structure of inositol monophosphatase, the putative target of lithium therapy. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 89:10031-10035(1992). | |
| PubMed ID | 1332026 |
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