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It has been shown [1] that several proteins share two sequence motifs. Two of
these proteins are enzymes of the inositol phosphate second messenger
signalling pathway:
Vertebrate, plants and microbial myo-inositol monophosphatase
(EC 3.1.3.25).
The function of the other proteins is not yet clear:
Bacterial protein cysQ. CysQ could help to control the pool of PAPS
(3'-phosphoadenoside 5'-phosphosulfate), or be useful in sulfite synthesis.
Neurospora crassa protein Qa-X. Probably involved in quinate metabolism.
Emericella nidulans protein qutG. Probably involved in quinate metabolism.
Yeast protein HAL2/MET22 [2] involved in salt tolerance as well as
methionine biosynthesis.
Yeast hypothetical hypothetical protein YHR046c.
Caenorhabditis elegans hypothetical protein F13G3.5.
It is suggested [1] that these proteins may act by enhancing the synthesis or
degradation of phosphorylated messenger molecules. From the X-ray structure of
human inositol monophosphatase [3], it seems that some of the conserved
residues are involved in binding a metal ion and/or the phosphate group of the
substrate.
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