PROSITE documentation PDOC00549
Ribosomal protein S4 signature


Ribosomal protein S4 is one of the proteins from the small ribosomal subunit. In Escherichia coli, S4 is known to bind directly to 16S ribosomal RNA. Mutations in S4 have been shown to increase translational error frequencies. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2], groups:

  • Eubacterial S4.
  • Algal and plant chloroplast S4.
  • Cyanelle S4.
  • Archaebacterial S4.
  • Mammalian S9.
  • Yeast YS11 (SUP46).
  • Marchantia polymorpha mitochondrial S4.
  • Dictyostelium discoideum rp1024.
  • Yeast protein NAM9 [3]. NAM9 has been characterized as a suppressor for ochre mutations in mitochondrial DNA. It could be a ribosomal protein that acts as a suppressor by decreasing translation accuracy.

S4 is a protein of 171 to 205 amino-acid residues (except for NAM9 which is much larger). The signature pattern for this protein is based on a conserved region located in the central section of these proteins.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_S4, PS00632; Ribosomal protein S4 signature  (PATTERN)


1AuthorsMizuta K. Hashimoto T. Suzuki K.I. Otaka E.
TitleYeast ribosomal proteins: XII. YS11 of Saccharomyces cerevisiae is a homologue to E. coli S4 according to the gene analysis.
SourceNucleic Acids Res. 19:2603-2608(1991).
PubMed ID2041737

2AuthorsOtaka E. Hashimoto T. Mizuta K.
SourceProtein Seq. Data Anal. 5:285-300(1993).

3AuthorsBoguta M. Dmochowska A. Borsuk P. Wrobel K. Gargouri A. Lazowska J. Slonimski P.P. Szczesniak B. Kruszewska A.
TitleNAM9 nuclear suppressor of mitochondrial ochre mutations in Saccharomyces cerevisiae codes for a protein homologous to S4 ribosomal proteins from chloroplasts, bacteria, and eucaryotes.
SourceMol. Cell. Biol. 12:402-412(1992).
PubMed ID1729612

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