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PROSITE documentation PDOC00549 |
Ribosomal protein S4 is one of the proteins from the small ribosomal subunit. In Escherichia coli, S4 is known to bind directly to 16S ribosomal RNA. Mutations in S4 have been shown to increase translational error frequencies. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2], groups:
S4 is a protein of 171 to 205 amino-acid residues (except for NAM9 which is much larger). The signature pattern for this protein is based on a conserved region located in the central section of these proteins.
Last update:April 2006 / Pattern revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Mizuta K. Hashimoto T. Suzuki K.I. Otaka E. |
Title | Yeast ribosomal proteins: XII. YS11 of Saccharomyces cerevisiae is a homologue to E. coli S4 according to the gene analysis. | |
Source | Nucleic Acids Res. 19:2603-2608(1991). | |
PubMed ID | 2041737 |
2 | Authors | Otaka E. Hashimoto T. Mizuta K. |
Source | Protein Seq. Data Anal. 5:285-300(1993). |
3 | Authors | Boguta M. Dmochowska A. Borsuk P. Wrobel K. Gargouri A. Lazowska J. Slonimski P.P. Szczesniak B. Kruszewska A. |
Title | NAM9 nuclear suppressor of mitochondrial ochre mutations in Saccharomyces cerevisiae codes for a protein homologous to S4 ribosomal proteins from chloroplasts, bacteria, and eucaryotes. | |
Source | Mol. Cell. Biol. 12:402-412(1992). | |
PubMed ID | 1729612 |