|PROSITE documentation PDOC00577|
The zona pellucida (ZP) domain is a protein polymerization module of ~260 amino acid module, which is found at the C-terminus of many secreted eukaryotic glycoproteins that play fundamental roles in development, hearing, immunity, and cancer [1,2,3,4]:
Most ZP domain proteins are synthesized as precursors with carboxy-terminal transmembrane domains or glycosyl phosphatidylinositol (GPI) anchors .
The ZP domain contains eight strictly conserved cysteines, which form disulfide bridges. The disulfide bonds within the ZP domains are divided into two groups, suggesting that the ZP domain consists of two subdomains. In addition to the conserved cysteines, only a few aromatic or hydrophobic amino acids are absolutely invariant, probably as a result of structural rather than functional constraints [1,3,4].
The profile we developed covers the entire ZP domain.Note:
Endoglins are reported to contain a region of homology with the N- terminal third of the ZP domain . This truncated version of the ZP domain is not recognized by the profile.Expert(s) to contact by email:
December 2004 / Pattern and text revised.
PROSITE methods (with tools and information) covered by this documentation:
|1||Authors||Bork P. Sander C.|
|Title||A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor.|
|Source||FEBS Lett. 300:237-240(1992).|
|2||Authors||Jovine L. Qi H. Williams Z. Litscher E. Wassarman P.M.|
|Title||The ZP domain is a conserved module for polymerization of extracellular proteins.|
|Source||Nat. Cell Biol. 4:457-461(2002).|
|3||Authors||Yonezawa N. Nakano M.|
|Title||Identification of the carboxyl termini of porcine zona pellucida glycoproteins ZPB and ZPC.|
|Source||Biochem. Biophys. Res. Commun. 307:877-882(2003).|
|4||Authors||Jovine L. Qi H. Williams Z. Litscher E.S. Wassarman P.M.|
|Title||A duplicated motif controls assembly of zona pellucida domain proteins.|
|Source||Proc. Natl. Acad. Sci. U.S.A. 101:5922-5927(2004).|
|5||Authors||Ge A.Z. Butcher E.C.|
|Title||Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand.|