PROSITE documentation PDOC00582
Enterobacterial virulence outer membrane protein signatures


A number of enterobacterial outer membrane proteins which are involved in virulence and seem to promote the invasion of bacteria into eukaryotic cells have been shown [1,2] to be structurally related. These proteins are listed below.

  • Escherichia coli and Enterobacter cloacae outer membrane protein X (gene ompX).
  • Salmonella typhimurium virulence membrane protein pagC.
  • Yersinia enterocolitica attachment invasion locus protein (gene ail).
  • Bacteriophage lambda outer membrane protein lom. Lom is expressed during lysogeny in Escherichia coli.

These outer membrane proteins have from 150 to 170 amino acid residues and their sequences are well conserved. We selected the two most highly conserved regions as signature patterns. The first pattern is located in the N-terminal section of these proteins; the second is located at the C-terminal extremity.

Last update:

November 1995 / Text revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

ENT_VIR_OMP_1, PS00694; Enterobacterial virulence outer membrane protein signature 1  (PATTERN)

ENT_VIR_OMP_2, PS00695; Enterobacterial virulence outer membrane protein signature 2  (PATTERN)


1Authorsvan de Klundert J.A.M.
SourceJ. Bacteriol. 173:156-160(1991).

2AuthorsPulkkinen W.S. Miller S.I.
TitleA Salmonella typhimurium virulence protein is similar to a Yersinia enterocolitica invasion protein and a bacteriophage lambda outer membrane protein.
SourceJ. Bacteriol. 173:86-93(1991).
PubMed ID1846140

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