PROSITE documentation PDOC00596Stress-induced proteins SRP1/TIP1 family signature
It has been recently shown [1] that three yeast proteins, two of which are known to be induced by various stress conditions, are structurally related and are probably part of a larger family. These proteins are listed below.
- Cold-shock inducible protein TIR1 (also known as serine-rich protein 1 (SRP1)). TIR1 is induced by glucose [2] and cold shock [3].
- Temperature-shock inducible protein 1 (TIP1). TIP1 can be induced by both cold and heat shocks [4].
- Cold-shock inducible protein TIR2 (SRP2) [3].
- Seripauperins, which are closely related protein of about 13 Kd (120 to 124 residues) which are generally encoded at the extremity of yeast chromosomes [5]. The known members of this family are: PAU1, PAU2, PAU3, PAU4, PAU5, PAU6, YBR301w, YGL261c, YGR294w, YHL046c, YIL176c, YIR041w and YKL224c.
- Hypothetical protein YIL011w.
- Hypothetical protein YJR150c.
- Hypothetical protein YJR151c.
These proteins all seem to start with a putative signal sequence followed by a conserved domain of about 90 residues. In TIR1, TIR2, TIP1, YIL011w, YJR150c and YJR151c, this domain is followed by a repetitive serine and alanine rich region absent in the other members of this family.
As a signature pattern for this protein family, we selected a region at the C-terminus of the conserved domain.
Last update:November 1997 / Text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Bork P. Ouzounis C. Sander C. Scharf M. Schneider R. Sonnhammer E. |
| Title | Comprehensive sequence analysis of the 182 predicted open reading frames of yeast chromosome III. | |
| Source | Protein Sci. 1:1677-1690(1992). | |
| PubMed ID | 1304897 |
| 2 | Authors | Marguet D. Guo X.J. Lauquin G.J.-M. |
| Title | Yeast gene SRP1 (serine-rich protein). Intragenic repeat structure and identification of a family of SRP1-related DNA sequences. | |
| Source | J. Mol. Biol. 202:455-470(1988). | |
| PubMed ID | 3139887 |
| 3 | Authors | Kowalski L.R.Z. Kondo K. Inouye M. |
| Title | Cold-shock induction of a family of TIP1-related proteins associated with the membrane in Saccharomyces cerevisiae. | |
| Source | Mol. Microbiol. 15:341-353(1995). | |
| PubMed ID | 7746155 |
| 4 | Authors | Kondo K. Inouye M. |
| Title | TIP 1, a cold shock-inducible gene of Saccharomyces cerevisiae. | |
| Source | J. Biol. Chem. 266:17537-17544(1991). | |
| PubMed ID | 1894636 |
| 5 | Authors | Viswanathan M. Muthukumar G. Cong Y.-S. Lenard J. |
| Title | Seripauperins of Saccharomyces cerevisiae: a new multigene family encoding serine-poor relatives of serine-rich proteins. | |
| Source | Gene 148:149-153(1994). | |
| PubMed ID | 7926827 |
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