PROSITE documentation PDOC00596
Stress-induced proteins SRP1/TIP1 family signature


It has been recently shown [1] that three yeast proteins, two of which are known to be induced by various stress conditions, are structurally related and are probably part of a larger family. These proteins are listed below.

  • Cold-shock inducible protein TIR1 (also known as serine-rich protein 1 (SRP1)). TIR1 is induced by glucose [2] and cold shock [3].
  • Temperature-shock inducible protein 1 (TIP1). TIP1 can be induced by both cold and heat shocks [4].
  • Cold-shock inducible protein TIR2 (SRP2) [3].
  • Seripauperins, which are closely related protein of about 13 Kd (120 to 124 residues) which are generally encoded at the extremity of yeast chromosomes [5]. The known members of this family are: PAU1, PAU2, PAU3, PAU4, PAU5, PAU6, YBR301w, YGL261c, YGR294w, YHL046c, YIL176c, YIR041w and YKL224c.
  • Hypothetical protein YIL011w.
  • Hypothetical protein YJR150c.
  • Hypothetical protein YJR151c.

These proteins all seem to start with a putative signal sequence followed by a conserved domain of about 90 residues. In TIR1, TIR2, TIP1, YIL011w, YJR150c and YJR151c, this domain is followed by a repetitive serine and alanine rich region absent in the other members of this family.

As a signature pattern for this protein family, we selected a region at the C-terminus of the conserved domain.

Last update:

November 1997 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SRP1_TIP1, PS00724; Stress-induced proteins SRP1/TIP1 family signature  (PATTERN)


1AuthorsBork P. Ouzounis C. Sander C. Scharf M. Schneider R. Sonnhammer E.
TitleComprehensive sequence analysis of the 182 predicted open reading frames of yeast chromosome III.
SourceProtein Sci. 1:1677-1690(1992).
PubMed ID1304897

2AuthorsMarguet D. Guo X.J. Lauquin G.J.-M.
TitleYeast gene SRP1 (serine-rich protein). Intragenic repeat structure and identification of a family of SRP1-related DNA sequences.
SourceJ. Mol. Biol. 202:455-470(1988).
PubMed ID3139887

3AuthorsKowalski L.R.Z. Kondo K. Inouye M.
TitleCold-shock induction of a family of TIP1-related proteins associated with the membrane in Saccharomyces cerevisiae.
SourceMol. Microbiol. 15:341-353(1995).
PubMed ID7746155

4AuthorsKondo K. Inouye M.
TitleTIP 1, a cold shock-inducible gene of Saccharomyces cerevisiae.
SourceJ. Biol. Chem. 266:17537-17544(1991).
PubMed ID1894636

5AuthorsViswanathan M. Muthukumar G. Cong Y.-S. Lenard J.
TitleSeripauperins of Saccharomyces cerevisiae: a new multigene family encoding serine-poor relatives of serine-rich proteins.
SourceGene 148:149-153(1994).
PubMed ID7926827

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