PROSITE documentation PDOC00644
Erythropoietin / thrombopoeitin signature


Erythropoietin (EPO) [1] is the mammalian hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of erythrocytes in the bloodstream. The mature form of EPO is a glycoprotein of 166 amino acid residues.

Thrombopoeitin (TPO) [2] is the mammalian hormone which functions as a megakaryocytic lineage specific growth and differentiation factor. It acts as a circulating regulator of platelet numbers. The mature form of TPO is a glycoprotein of 330 amino acid residues.

EPO and TPO are evolutionary related. As a signature pattern, we selected a conserved region located at the N-terminal extremity of mature EPO and TPO and that includes two cysteines which have been shown, in human EPO, to be implicated in disulfide bonds.

Last update:

May 2004 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

EPO_TPO, PS00817; Erythropoietin / thrombopoeitin signature  (PATTERN)


1AuthorsKoury M.J. Bondurant M.C.
TitleThe molecular mechanism of erythropoietin action.
SourceEur. J. Biochem. 210:649-663(1992).
PubMed ID1483451

2AuthorsDe Sauvage F.J. Hass P.E. Spencer S.D. Malloy B.E. Gurney A.L. Spencer S.A. Darbonne W.C. Henzel W.J. Wong S.C. Kuang W.J. Oles K.J. Hultgren B. Solberg L.A. Jr. Goeddel D.V. Eaton D.L.
SourceNature 369:533-538(1994).

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