PROSITE documentation PDOC00647Cytochrome c and c1 heme lyases signatures
Cytochrome c heme lyase (CCHL) (EC 4.4.1.17) and cytochrome c1 heme lyase (CC1HL) [1] are mitochondrial enzymes that catalyze the covalent attachment of a heme group on two cysteine residues of cytochrome c and c1.
These two enzymes are functionally and evolutionary related. As signature patterns, we selected two conserved regions: the first is located in the central section and the second in the C-terminal section. Both patterns contain conserved histidine, tryptophan and acidic residues which could be important for the interaction of the enzymes with the apoproteins and/or the heme group.
Last update:December 2004 / Pattern and text revised.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Zollner A. Roedel G. Haid A. |
| Title | Molecular cloning and characterization of the Saccharomyces cerevisiae CYT2 gene encoding cytochrome-c1-heme lyase. | |
| Source | Eur. J. Biochem. 207:1093-1100(1992). | |
| PubMed ID | 1499554 |
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