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PROSITE documentation PDOC00647

Cytochrome c and c1 heme lyases signatures


Cytochrome c heme lyase (CCHL) (EC and cytochrome c1 heme lyase (CC1HL) [1] are mitochondrial enzymes that catalyze the covalent attachment of a heme group on two cysteine residues of cytochrome c and c1.

These two enzymes are functionally and evolutionary related. As signature patterns, we selected two conserved regions: the first is located in the central section and the second in the C-terminal section. Both patterns contain conserved histidine, tryptophan and acidic residues which could be important for the interaction of the enzymes with the apoproteins and/or the heme group.

Last update:

December 2004 / Pattern and text revised.

Technical section

PROSITE methods (with tools and information) covered by this documentation:

CYTO_HEME_LYASE_1, PS00821; Cytochrome c and c1 heme lyases signature 1  (PATTERN)

CYTO_HEME_LYASE_2, PS00822; Cytochrome c and c1 heme lyases signature 2  (PATTERN)


1AuthorsZollner A. Roedel G. Haid A.
TitleMolecular cloning and characterization of the Saccharomyces cerevisiae CYT2 gene encoding cytochrome-c1-heme lyase.
SourceEur. J. Biochem. 207:1093-1100(1992).
PubMed ID1499554

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