|PROSITE documentation PDOC00647|
Cytochrome c heme lyase (CCHL) (EC 184.108.40.206) and cytochrome c1 heme lyase (CC1HL)  are mitochondrial enzymes that catalyze the covalent attachment of a heme group on two cysteine residues of cytochrome c and c1.
These two enzymes are functionally and evolutionary related. As signature patterns, we selected two conserved regions: the first is located in the central section and the second in the C-terminal section. Both patterns contain conserved histidine, tryptophan and acidic residues which could be important for the interaction of the enzymes with the apoproteins and/or the heme group.Last update:
December 2004 / Pattern and text revised.
PROSITE methods (with tools and information) covered by this documentation:
|1||Authors||Zollner A. Roedel G. Haid A.|
|Title||Molecular cloning and characterization of the Saccharomyces cerevisiae CYT2 gene encoding cytochrome-c1-heme lyase.|
|Source||Eur. J. Biochem. 207:1093-1100(1992).|