PROSITE documentation PDOC00655
Interleukins -4 and -13 signature


Interleukin-4 (IL-4) [1,2] is a cytokine that plays a central role in the control and regulation of the immune and inflammatory system. IL-4 is a participant in several B-cell activation processes. It also stimulates other cell types such as T cells or mast cells. IL-4 is a glycoprotein of 110 to 131 residues. It contains three disulfide bonds. The position of these disulfide bonds is not highly conserved since the topology of two of them differs in Human and mouse IL-4 [3].

Interleukin-13 [4] (IL-13) is a recently discovered pleiotropic cytokine which may be important in the regulation of the inflammatory and immune responses. IL-13 is a glycoprotein of 110 residues.

The sequence of IL-4 and IL-13 are distantly related. As a signature pattern we selected the best conserved region which is located in the N-terminal part of these proteins. This region contains a cysteine which, in IL-4, is involved in the sole disulfide bond conserved between human and mouse IL-4.

Last update:

December 2001 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

INTERLEUKIN_4_13, PS00838; Interleukins -4 and -13 signature  (PATTERN)


1AuthorsYokota T. Arai N. Vries J.D. Spits H. Banchereau J. Zlotnik A. Rennik D. Howard M. Takebe Y. Miyatake S. Lee F. Arai K.-I.
SourceImmunol. Rev. 103:137-187(1988).

2AuthorsFinkelman F.D. Holmes J. Katona I.M. Urban J.F. Jr. Beckmann M.P. Park L.S. Schooley K.A. Coffman R.L. Mosmann T.R. Paul W.E.
TitleLymphokine control of in vivo immunoglobulin isotype selection.
SourceAnnu. Rev. Immunol. 8:303-333(1990).
PubMed ID1693082

3AuthorsCarr C. Aykent S. Kimack N.M. Levine A.D.
TitleDisulfide assignments in recombinant mouse and human interleukin 4.
SourceBiochemistry 30:1515-1523(1991).
PubMed ID1993171

4AuthorsMinty A. Chalon P. Derocq J.-M. Dumont X. Guillemot J.-C. Kaghad M. Labit C. Leplatois P. Liauzun P. Miloux B. Minty C. Casellas P. Loison G. Lupker J. Shire D. Ferrara P. Caput D.
TitleInterleukin-13 is a new human lymphokine regulating inflammatory and immune responses.
SourceNature 362:248-250(1993).
PubMed ID8096327

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