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PROSITE documentation PDOC00673

Galanin signature





Description

Galanin [1,2,3] is a neuropeptide that controls various biological activities: it regulates the release growth hormone, inhibits the release of insulin and somatostatin, contracts smooth muscle of the gastrointestinal and genitourinary tract and may be involved in the control of adrenal secretion.

Galanin is a 29 amino acid peptide processed from a larger precursor protein. Except in human, galanin is C-terminally amidated.

A galanin-like peptide (GALP) has recently been identified [4].

The sequence is of galanin and of GALP are highly conserved and the first 13 residues are identical in all currently known sequences. We have used this N-terminal sequence as a signature pattern.

Last update:

February 2002 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

GALANIN, PS00861; Galanin signature  (PATTERN)


References

1AuthorsRoekaeus A.
SourceTrends Neurosci. 10:158-164(1987).

2AuthorsBartfai T. Fisone G. Langel U.
TitleGalanin and galanin antagonists: molecular and biochemical perspectives.
SourceTrends Pharmacol. Sci. 13:312-317(1992).
PubMed ID1384214

3AuthorsVrontakis M.E. Torsello A. Friesen H.G.
TitleGalanin.
SourceJ. Endocrinol. Invest. 14:785-794(1991).
PubMed ID1722230

4AuthorsOhtaki T. Kumano S. Ishibashi Y. Ogi K. Matsui H. Harada M. Kitada C. Kurokawa T. Onda H. Fujino M.
TitleIsolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus.
SourceJ. Biol. Chem. 274:37041-37045(1999).
PubMed ID10601261



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