PROSITE documentation PDOC00681
Sodium:alanine symporter family signature


It has been shown [1] that integral membrane proteins that mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. One of these families is known as the sodium:alanine symporter family (SAF) and currently consists of the following proteins:

  • Thermophilic bacterium PS-3 alanine carrier protein (ACP). ACP can use both sodium and hydrogen as a symport ion.
  • Alteromonas haloplanktis D-alanine/glycine permease (gene dagA).
  • Bacillus subtilis alsT.
  • Hypothetical protein yaaJ from Escherichia coli and HI0183, the corresponding Haemophilus influenzae protein.
  • Haemophilus influenzae hypothetical protein HI0883.

These integral membrane proteins are predicted to comprise a least eight membrane spanning domains. As a signature pattern we selected a highly conserved region which is located in the N-terminal section and which includes part of the first transmembrane region.

Last update:

November 1997 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

NA_ALANINE_SYMP, PS00873; Sodium:alanine symporter family signature  (PATTERN)


1AuthorsReizer J. Reizer A. Saier M.H. Jr.
TitleA functional superfamily of sodium/solute symporters.
SourceBiochim. Biophys. Acta 1197:133-166(1994).
PubMed ID8031825

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