Home  |  Contact
PROSITE documentation PDOC00689

Osteopontin signature





Description

Osteopontin is an acidic phosphorylated glycoprotein of about 40 Kd which is abundant in the mineral matrix of bones and which binds tightly to hydroxyapatite [1,2,3]. It is suggested that osteopontin might function as a cell attachment factor and could play a key role in the adhesion of osteoclasts to the mineral matrix of bone.

Osteopontin-K is a kidney protein which is highly similar to osteopontin and probably also involved in cell-adhesion.

As a signature pattern we selected a highly conserved region located at the N-terminal extremity of the mature protein.

Last update:

June 1994 / Text revised.

-------------------------------------------------------------------------------

Technical section

PROSITE method (with tools and information) covered by this documentation:

OSTEOPONTIN, PS00884; Osteopontin signature  (PATTERN)


References

1AuthorsButler W.T.
TitleThe nature and significance of osteopontin.
SourceConnect. Tissue Res. 23:123-136(1989).
PubMed ID2698313

2AuthorsGorski J.P.
TitleAcidic phosphoproteins from bone matrix: a structural rationalization of their role in biomineralization.
SourceCalcif. Tissue Int. 50:391-396(1992).
PubMed ID1596774

3AuthorsDenhardt D.T. Guo X.
TitleOsteopontin: a protein with diverse functions.
SourceFASEB J. 7:1475-1482(1993).
PubMed ID8262332



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)