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PROSITE documentation PDOC00698 |
In bacteria there are a number of families of transport proteins that mediate the intake of a variety of sugars with the concomitant uptake of hydrogen ions (proton symporters) [1]. One of these families is composed [2] of the following proteins:
These integral membrane proteins are predicted to comprise twelve membrane spanning domains. As signature patterns we selected two conserved regions that both correspond to cytoplasmic loops: between the second and third transmembrane regions for the first pattern and between the eight and ninth for the second pattern.
Last update:October 1993 / First entry.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Marger M.D. Saier M.H. Jr. |
Title | A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport. | |
Source | Trends Biochem. Sci. 18:13-20(1993). | |
PubMed ID | 8438231 |
2 | Authors | Bockmann J. Heuel H. Lengeler J.W. |
Title | Characterization of a chromosomally encoded, non-PTS metabolic pathway for sucrose utilization in Escherichia coli EC3132. | |
Source | Mol. Gen. Genet. 235:22-32(1992). | |
PubMed ID | 1435727 |