PROSITE documentation PDOC00704
GTP1/OBG family signature


A widespread family of GTP-binding proteins has been recently characterized [1,2]. This family currently includes:

  • Mouse and Xenopus protein DRG.
  • Human protein DRG2.
  • Drosophila protein 128up.
  • Fission yeast protein gtp1.
  • A Halobacterium cutirubrum hypothetical protein in a ribosomal protein gene cluster.
  • Bacillus subtilis protein obg. Obg has been experimentally shown to bind GTP.
  • Escherichia coli hypothetical protein yhbZ.
  • Haemophilus influenzae hypothetical protein HI0877.
  • Mycoplasma genitalium hypothetical protein MG384.
  • Yeast hypothetical protein YAL036c (FUN11).
  • Yeast hypothetical protein YGR173w.
  • Caenorhabditis elegans hypothetical protein C02F5.3.

The function of the proteins that belong to this family is not yet known. They are polypeptides of about 40 to 48 Kd which contain the five small sequence elements characteristic of GTP-binding proteins [3]. As a signature pattern we selected the region that correspond to the ATP/GTP B motif (also called G-3 in GTP-binding proteins).

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

GTP1_OBG, PS00905; GTP1/OBG family signature  (PATTERN)


1AuthorsSazuka T. Tomooka Y. Ikawa Y. Noda M. Kumar S.
TitleDRG: a novel developmentally regulated GTP-binding protein.
SourceBiochem. Biophys. Res. Commun. 189:363-370(1992).
PubMed ID1449490

2AuthorsHudson J.D. Young P.G.
TitleSequence of the Schizosaccharomyces pombe gtp1 gene and identification of a novel family of putative GTP-binding proteins.
SourceGene 125:191-193(1993).
PubMed ID8462872

3AuthorsBourne H.R. Sanders D.A. McCormick F.
TitleThe GTPase superfamily: conserved structure and molecular mechanism.
SourceNature 349:117-127(1991).
PubMed ID1898771

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