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PROSITE documentation PDOC00704 |
A widespread family of GTP-binding proteins has been recently characterized [1,2]. This family currently includes:
The function of the proteins that belong to this family is not yet known. They are polypeptides of about 40 to 48 Kd which contain the five small sequence elements characteristic of GTP-binding proteins [3]. As a signature pattern we selected the region that correspond to the ATP/GTP B motif (also called G-3 in GTP-binding proteins).
Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Sazuka T. Tomooka Y. Ikawa Y. Noda M. Kumar S. |
Title | DRG: a novel developmentally regulated GTP-binding protein. | |
Source | Biochem. Biophys. Res. Commun. 189:363-370(1992). | |
PubMed ID | 1449490 |
2 | Authors | Hudson J.D. Young P.G. |
Title | Sequence of the Schizosaccharomyces pombe gtp1 gene and identification of a novel family of putative GTP-binding proteins. | |
Source | Gene 125:191-193(1993). | |
PubMed ID | 8462872 |
3 | Authors | Bourne H.R. Sanders D.A. McCormick F. |
Title | The GTPase superfamily: conserved structure and molecular mechanism. | |
Source | Nature 349:117-127(1991). | |
PubMed ID | 1898771 | |
DOI | 10.1038/349117a0 |