We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00727UbiA prenyltransferase family signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00727
Description
The following prenyltransferases are evolutionary related [1,2]:
- Bacterial 4-hydroxybenzoate octaprenyltransferase (gene ubiA).
- Yeast mitochondrial para-hydroxybenzoate--polyprenyltransferase (gene COQ2).
- Protoheme IX farnesyltransferase (heme O synthase) from yeast and mammals (gene COX10) and from bacteria (genes cyoE or ctaB).
These proteins probably contain seven transmembrane segments. The best conserved region is located in a loop between the second and third of these segments and we used it as a signature pattern.
Last update:April 2006 / Pattern revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Melzer M. Heide L. |
| Title | Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli. | |
| Source | Biochim. Biophys. Acta 1212:93-102(1994). | |
| PubMed ID | 8155731 |
| 2 | Authors | Mogi T. Saiki K. Anraku Y. |
| Title | Biosynthesis and functional role of haem O and haem A. | |
| Source | Mol. Microbiol. 14:391-398(1994). | |
| PubMed ID | 7885224 |
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