PROSITE documentation PDOC00728
Cyclin-dependent kinases regulatory subunits signatures


Cyclin-dependent kinases (CDK) are protein kinases which associate with cyclins to regulate eukaryotic cell cycle progression. The most well known CDK is p34-cdc2 (CDC28 in yeast) which is required for entry into S-phase and mitosis. CDK's bind to a regulatory subunit which is essential for their biological function. This regulatory subunit is a small protein of 79 to 150 residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known, while mammals have two highly related isoforms.

It has been shown [1] that these CDK regulatory subunits assemble as an hexamer which then acts as a hub for the oligomerization of six CDK catalytic subunits.

The sequence of CDK regulatory subunits are highly conserved and we used the two most conserved regions as signature patterns.

Last update:

November 1997 / Patterns and text revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

CKS_1, PS00944; Cyclin-dependent kinases regulatory subunits signature 1  (PATTERN)

CKS_2, PS00945; Cyclin-dependent kinases regulatory subunits signature 2  (PATTERN)


1AuthorsParge H.E. Arvai A.S. Murtari D.J. Reed S.I. Tainer J.A.
TitleHuman CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.
SourceScience 262:387-395(1993).
PubMed ID8211159

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