PROSITE documentation PDOC00738
Imidazoleglycerol-phosphate dehydratase signatures


Imidazoleglycerol-phosphate dehydratase (EC is the enzyme that catalyzes the seventh step in the biosynthesis of histidine in bacteria, fungi and plants. In most organisms it is a monofunctional protein of about 22 to 29 Kd. In some bacteria such as Escherichia coli it is the C-terminal domain of a bifunctional protein that include a histidinol-phosphatase domain [1].

We developed two signature patterns that each include two consecutive histidine residues.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

IGP_DEHYDRATASE_1, PS00954; Imidazoleglycerol-phosphate dehydratase signature 1  (PATTERN)

IGP_DEHYDRATASE_2, PS00955; Imidazoleglycerol-phosphate dehydratase signature 2  (PATTERN)


1AuthorsCarlomagno M.S. Chiariotti L. Alifano P. Nappo A.G. Bruni C.B.
TitleStructure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons.
SourceJ. Mol. Biol. 203:585-606(1988).
PubMed ID3062174

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