PROSITE documentation PDOC00738Imidazoleglycerol-phosphate dehydratase signatures
Description
Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19) is the enzyme that catalyzes the seventh step in the biosynthesis of histidine in bacteria, fungi and plants. In most organisms it is a monofunctional protein of about 22 to 29 Kd. In some bacteria such as Escherichia coli it is the C-terminal domain of a bifunctional protein that include a histidinol-phosphatase domain [1].
We developed two signature patterns that each include two consecutive histidine residues.
Last update:April 2006 / Pattern revised.
-------------------------------------------------------------------------------
Technical section
PROSITE methods (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Carlomagno M.S. Chiariotti L. Alifano P. Nappo A.G. Bruni C.B. |
| Title | Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons. | |
| Source | J. Mol. Biol. 203:585-606(1988). | |
| PubMed ID | 3062174 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
Miscellaneous
View entry in original PROSITE document format
View entry in raw text format (no links)