PROSITE documentation PDOC00739
Fungal hydrophobins signature


The surface of many fungal spores is covered by a hydrophobic sheath, the rodlet layer whose main component is a protein known as the rodlet protein [1,2]. The rodlet proteins of Neurospora crassa (gene eas) and Emericella nidulans (gene rodA) are evolutionary related to proteins found in the cell wall of fruiting bodies of the mushroom Schizophyllum commune [3]. Collectively, these low-molecular-weight, cysteine-rich (8 conserved cysteines), hydrophobic proteins, are known as hydrophobins.

As a signature pattern we selected a conserved region that contains three cysteines and which is located in the C-terminal section.

Last update:

November 1997 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HYDROPHOBIN, PS00956; Fungal hydrophobins signature  (PATTERN)


1AuthorsStringer M.A. Dean R.A. Sewall T.C. Timberlake W.E.
TitleRodletless, a new Aspergillus developmental mutant induced by directed gene inactivation.
SourceGenes Dev. 5:1161-1171(1991).
PubMed ID2065971

2AuthorsLauter F.-R. Russo V.E.A. Yanofsky C.
TitleDevelopmental and light regulation of eas, the structural gene for the rodlet protein of Neurospora.
SourceGenes Dev. 6:2373-2381(1992).
PubMed ID1459459

3AuthorsSchuren F.H.J. Wessels J.G.
TitleTwo genes specifically expressed in fruiting dikaryons of Schizophyllum commune: homologies with a gene not regulated by mating-type genes.
SourceGene 90:199-205(1990).
PubMed ID2401401

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