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	PROSITE documentation PDOC00740

NAD-dependent glycerol-3-phosphate dehydrogenase signature

NAD-dependent glycerol-3-phosphate dehydrogenase (EC 1.1.1.8) (GPD) catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate. It is a eukaryotic cytosolic homodimeric protein of about 40 Kd. As a signature pattern we selected a glycine-rich region that is probably [1] involved in NAD-binding.

Last update:

April 2006 / Pattern revised.

PROSITE method (with tools and information) covered by this documentation:

NAD_G3PDH, PS00957; NAD-dependent glycerol-3-phosphate dehydrogenase signature  (PATTERN)

• Consensus pattern:
  [GSA]-[ATIVS]-[LIVMYCAFST]-K-[DN]-[LIVMA]-[LIVMFYT]-[GA]- x-[GACKMSIFT]-x-G-[ALIVMF]-x(2)-[SGAQ]-[LIVMYERAKQFS]- x(0,1)-[TLIVMFYWAQ]-[ETGAS]-x(0,1)-[NDVS]
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 641
  • detected by PS00957: 615 (true positives)
  • undetected by PS00957: 26 (26 false negatives and 0 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00957:
  NONE.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00957
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00957
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS00957
• View ligand binding statistics of PS00957
• Matching PDB structures: 1EVY 1EVZ 1JDJ 1M66 ... [ALL]

1	Authors	Otto J. Argos P. Rossmann M.G.
	Title	Prediction of secondary structural elements in glycerol-3-phosphate dehydrogenase by comparison with other dehydrogenases.
	Source	Eur. J. Biochem. 109:325-330(1980).
	PubMed ID	6773774

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