We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00740NAD-dependent glycerol-3-phosphate dehydrogenase signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00740
Description
NAD-dependent glycerol-3-phosphate dehydrogenase (EC 1.1.1.8) (GPD) catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate. It is a eukaryotic cytosolic homodimeric protein of about 40 Kd. As a signature pattern we selected a glycine-rich region that is probably [1] involved in NAD-binding.
Last update:April 2006 / Pattern revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Otto J. Argos P. Rossmann M.G. |
| Title | Prediction of secondary structural elements in glycerol-3-phosphate dehydrogenase by comparison with other dehydrogenases. | |
| Source | Eur. J. Biochem. 109:325-330(1980). | |
| PubMed ID | 6773774 |
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