PROSITE documentation PDOC00747Neuromedin U signature
Description
Neuromedin U (NmU) [1] is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C-terminally amidated.
The sequence of the C-terminal extremity of NmU is extremely well conserved [2] in mammals, birds and amphibians. We used the last seven residues as a signature pattern.
Last update:June 1994 / First entry.
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Technical section
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References
1 | Authors | Domin J. Polak J.M. Bloom S.R. |
Title | The distribution and biological effects of neuromedins B and U. | |
Source | Ann. N.Y. Acad. Sci. 547:391-403(1988). | |
PubMed ID | 3239891 |
2 | Authors | Domin J. Benito-Orfila M.A. Nandha K.A. Aitken A. Bloom S.R. |
Title | The purification and sequence analysis of an avian neuromedin U. | |
Source | Regul. Pept. 41:1-8(1992). | |
PubMed ID | 1455013 |
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