PROSITE logo

PROSITE documentation PDOC00747
Neuromedin U signature


Description

Neuromedin U (NmU) [1] is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C-terminally amidated.

The sequence of the C-terminal extremity of NmU is extremely well conserved [2] in mammals, birds and amphibians. We used the last seven residues as a signature pattern.

Last update:

June 1994 / First entry.

-------------------------------------------------------------------------------


Technical section

PROSITE method (with tools and information) covered by this documentation:

NMU, PS00967; Neuromedin U signature  (PATTERN)


References

1AuthorsDomin J. Polak J.M. Bloom S.R.
TitleThe distribution and biological effects of neuromedins B and U.
SourceAnn. N.Y. Acad. Sci. 547:391-403(1988).
PubMed ID3239891

2AuthorsDomin J. Benito-Orfila M.A. Nandha K.A. Aitken A. Bloom S.R.
TitleThe purification and sequence analysis of an avian neuromedin U.
SourceRegul. Pept. 41:1-8(1992).
PubMed ID1455013



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)