PROSITE documentation PDOC00747Neuromedin U signature
Description
Neuromedin U (NmU) [1] is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C-terminally amidated.
The sequence of the C-terminal extremity of NmU is extremely well conserved [2] in mammals, birds and amphibians. We used the last seven residues as a signature pattern.
Last update:June 1994 / First entry.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Domin J. Polak J.M. Bloom S.R. |
| Title | The distribution and biological effects of neuromedins B and U. | |
| Source | Ann. N.Y. Acad. Sci. 547:391-403(1988). | |
| PubMed ID | 3239891 |
| 2 | Authors | Domin J. Benito-Orfila M.A. Nandha K.A. Aitken A. Bloom S.R. |
| Title | The purification and sequence analysis of an avian neuromedin U. | |
| Source | Regul. Pept. 41:1-8(1992). | |
| PubMed ID | 1455013 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
Miscellaneous
View entry in original PROSITE document format
View entry in raw text format (no links)