We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00747Neuromedin U signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00747
Description
Neuromedin U (NmU) [1] is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C-terminally amidated.
The sequence of the C-terminal extremity of NmU is extremely well conserved [2] in mammals, birds and amphibians. We used the last seven residues as a signature pattern.
Last update:June 1994 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Domin J. Polak J.M. Bloom S.R. |
| Title | The distribution and biological effects of neuromedins B and U. | |
| Source | Ann. N.Y. Acad. Sci. 547:391-403(1988). | |
| PubMed ID | 3239891 |
| 2 | Authors | Domin J. Benito-Orfila M.A. Nandha K.A. Aitken A. Bloom S.R. |
| Title | The purification and sequence analysis of an avian neuromedin U. | |
| Source | Regul. Pept. 41:1-8(1992). | |
| PubMed ID | 1455013 |
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