PROSITE documentation PDOC00751
Mannitol dehydrogenases signature


The following dehydrogenases have been shown [1] to be evolutionary related:

  • Mannitol-1-phosphate 5-dehydrogenase (EC (gene mtlD), which catalyzes the NAD-dependent reduction of mannitol 1-phosphate into fructose 6-phosphate.
  • Mannitol 2-dehydrogenase (EC (gene mtlK), which catalyzes the NAD-dependent reduction of mannitol into fructose.
  • Mannonate oxidoreductase (EC (fructuronate reductase) (gene uxuB), which catalyzes the NAD-dependent reduction of fructuronate into mannonate.
  • Escherichia coli hypothetical protein ydfI.
  • Escherichia coli hypothetical protein yeiQ.
  • Yeast hypothetical protein YEL070w.

As a signature pattern, we selected a conserved region located in the central section of these enzymes.

Last update:

November 1997 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

MANNITOL_DHGENASE, PS00974; Mannitol dehydrogenases signature  (PATTERN)


1AuthorsSchneider K.-H. Giffhorn F. Kaplan S.
TitleCloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides.
SourceJ. Gen. Microbiol. 139:2475-2484(1993).
PubMed ID8254318

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