Mannitol dehydrogenases signature
The following dehydrogenases have been shown [
1] to be evolutionary related:
Mannitol-1-phosphate 5-dehydrogenase (EC
22.214.171.124) (gene mtlD), which
catalyzes the NAD-dependent reduction of mannitol 1-phosphate into fructose
Mannitol 2-dehydrogenase (EC
126.96.36.199) (gene mtlK), which catalyzes the
NAD-dependent reduction of mannitol into fructose.
Mannonate oxidoreductase (EC
188.8.131.52) (fructuronate reductase) (gene
uxuB), which catalyzes the NAD-dependent reduction of fructuronate into
Escherichia coli hypothetical protein ydfI.
Escherichia coli hypothetical protein yeiQ.
Yeast hypothetical protein YEL070w.
As a signature pattern, we selected a conserved region located in the central
section of these enzymes.
November 1997 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
PS00974; Mannitol dehydrogenases signature (PATTERN)
1 Authors Schneider K.-H. Giffhorn F. Kaplan S.
Title Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides.
Source J. Gen. Microbiol. 139:2475-2484(1993).
PubMed ID 8254318
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