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PROSITE documentation PDOC00758 |
A family of mammalian sperm proteins has been recently characterized [1,2]. The proteins that are currently known to belong to this family are:
As shown in the following schematic representation these proteins, which have from 110 to 130 amino acid residues, contain four conserved cysteines involved in two disulfide bonds.
+---------+ +---------+ | | | | xxxxCxxxxxxxxxCxxxxxxxxxxxCxxxxxxxxxCxxxxxxxxxxxxxxxxxx ************ ***********
'C': conserved cysteine involved in a disulfide bond. '*': position of the patterns.
Structurally, the spermadhesins consist of a CUB domain [3] (see <PDOC00908>).
Last update:May 2004 / Text revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Calvete J.J. Solis D. Sanz L. Diaz-Maurino T. Schafer W. Mann K. Topfer-Petersen E. |
Title | Characterization of two glycosylated boar spermadhesins. | |
Source | Eur. J. Biochem. 218:719-725(1993). | |
PubMed ID | 8269963 |
2 | Authors | Kwok S.C.M. Yang D. Dai G. Soares M.J. Chen S. McMurtry J.P. |
Title | Molecular cloning and sequence analysis of two porcine seminal proteins, PSP-I and PSP-II: new members of the spermadhesin family. | |
Source | DNA Cell Biol. 12:605-610(1993). | |
PubMed ID | 8397818 |
3 | Authors | Bork P. Beckmann G. |
Title | The CUB domain. A widespread module in developmentally regulated proteins. | |
Source | J. Mol. Biol. 231:539-545(1993). | |
PubMed ID | 8510165 |