PROSITE documentation PDOC00770
Transposases, Mutator family, signature


Autonomous mobile genetic elements such as transposon or insertion sequences (IS) encode an enzyme, called transposase, required for excising and inserting the mobile element. On the basis of sequence similarities, transposases can be grouped into various families. One of these families has been shown [1,2,3] to consist of transposases from the following elements:

  • Mutator from Maize.
  • Is1201 from Lactobacillus helveticus.
  • Is905 from Lactococcus lactis.
  • Is1081 from Mycobacterium bovis.
  • Is6120 from Mycobacterium smegmatis.
  • Is406 from Pseudomonas cepacia.
  • IsRm3 from Rhizobium meliloti.
  • IsRm5 from Rhizobium meliloti.
  • Is256 from Staphylococcus aureus.
  • IsT2 from Thiobacillus ferrooxidans.

The maize Mutator transposase (MudrA) is a protein of 823 amino acids; the bacterial transposases listed above are proteins of 300 to 420 amino acids. These proteins contain a conserved domain of about 130 residues; a signature pattern was derived from the most conserved part of this domain.

Expert(s) to contact by email:

Eisen J.A.

Last update:

July 1999 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

TRANSPOSASE_MUTATOR, PS01007; Transposases, Mutator family, signature  (PATTERN)


1AuthorsEisen J.A. Benito M.-I. Walbot V.
TitleSequence similarity of putative transposases links the maize Mutator autonomous element and a group of bacterial insertion sequences.
SourceNucleic Acids Res. 22:2634-2636(1994).
PubMed ID8041625

2AuthorsGuilhot C. Gicquel B. Davies J. Martin C.
TitleIsolation and analysis of IS6120, a new insertion sequence from Mycobacterium smegmatis.
SourceMol. Microbiol. 6:107-113(1992).
PubMed ID1310791

3AuthorsWood M.S. Byrne A. Lessie T.G.
TitleIS406 and IS407, two gene-activating insertion sequences for Pseudomonas cepacia.
SourceGene 105:101-105(1991).
PubMed ID1718819

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