PROSITE documentation PDOC00780Sterol reductase family signatures
Description
The following enzymes belong to a conserved family of sterol reductases which act by reducing double bonds [1,2]:
- Fungal delta(14)-sterol reductase (EC 1.3.1.70) (C-14 sterol reductase) (gene ERG24 in budding yeast), an enzyme of ergosterol biosynthesis.
- Mammalian (TM7SF2) and plant delta(14)-sterol reductases.
- Fungal delta(24(24(1)))-sterol reductase (EC 1.3.1.71) (C-24(28) sterol reductase) (gene ERG4 in budding yeast), an enzyme of ergosterol biosynthesis.
- Mammalian 7-dehydrocholesterol reductase (EC 1.3.1.21) which produces cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7- DHC).
- Lamin B receptor, which is thought to anchor the lamina to the inner nuclear membrane.
All these proteins are highly hydrophobic and seem to contain seven or eight transmembrane regions. As signature patterns, we selected two conserved regions. The first one is apparently located in a loop between the fourth and fifth transmembrane regions and the second is in the C-terminal section.
Last update:January 2002 / Patterns and text revised.
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Technical section
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References
1 | Authors | Lai M.H. Bard M. Pierson C.A. Alexander J.F. Goebl M. Carter G.T. Kirsch D.R. |
Title | The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway. | |
Source | Gene 140:41-49(1994). | |
PubMed ID | 8125337 |
2 | Authors | Holmer L. Pezhman A. Worman H.J. |
Title | The human lamin B receptor/sterol reductase multigene family. | |
Source | Genomics 54:469-476(1998). | |
PubMed ID | 9878250 |
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