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PROSITE documentation PDOC00780

Sterol reductase family signatures





Description

The following enzymes belong to a conserved family of sterol reductases which act by reducing double bonds [1,2]:

  • Fungal delta(14)-sterol reductase (EC 1.3.1.70) (C-14 sterol reductase) (gene ERG24 in budding yeast), an enzyme of ergosterol biosynthesis.
  • Mammalian (TM7SF2) and plant delta(14)-sterol reductases.
  • Fungal delta(24(24(1)))-sterol reductase (EC 1.3.1.71) (C-24(28) sterol reductase) (gene ERG4 in budding yeast), an enzyme of ergosterol biosynthesis.
  • Mammalian 7-dehydrocholesterol reductase (EC 1.3.1.21) which produces cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7- DHC).
  • Lamin B receptor, which is thought to anchor the lamina to the inner nuclear membrane.

All these proteins are highly hydrophobic and seem to contain seven or eight transmembrane regions. As signature patterns, we selected two conserved regions. The first one is apparently located in a loop between the fourth and fifth transmembrane regions and the second is in the C-terminal section.

Last update:

January 2002 / Patterns and text revised.

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Technical section

PROSITE methods (with tools and information) covered by this documentation:

STEROL_REDUCT_1, PS01017; Sterol reductase family signature 1  (PATTERN)

STEROL_REDUCT_2, PS01018; Sterol reductase family signature 2  (PATTERN)


References

1AuthorsLai M.H. Bard M. Pierson C.A. Alexander J.F. Goebl M. Carter G.T. Kirsch D.R.
TitleThe identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway.
SourceGene 140:41-49(1994).
PubMed ID8125337

2AuthorsHolmer L. Pezhman A. Worman H.J.
TitleThe human lamin B receptor/sterol reductase multigene family.
SourceGenomics 54:469-476(1998).
PubMed ID9878250



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