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PROSITE documentation PDOC00785Protein phosphatase 2A regulatory subunit PR55 signatures
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00785
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in many aspects of cellular function including the regulation of metabolic enzymes and proteins involved in signal transduction. PP2A is a trimeric enzyme that consists of a core composed of a catalytic subunit associated with a 65 Kd regulatory subunit (PR65), also called subunit A; this complex then associates with a third variable subunit (subunit B), which confers distinct properties to the holoenzyme [1]. One of the forms of the variable subunit is a 55 Kd protein (PR55) which is highly conserved in mammals - where three isoforms are known to exist -, Drosophila and yeast (gene CDC55). This subunit could perform a substrate recognition function or be responsible for targeting the enzyme complex to the appropriate subcellular compartment.
As signature patterns, we selected two perfectly conserved sequences of 15 residues; one located in the N-terminal region, the other in the center of the protein.
Expert(s) to contact by email: Last update:April 2006 / Pattern revised.
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| 1 | Authors | Mayer-Jaekel R. Hemmings B.A. |
| Title | Protein phosphatase 2A--a 'menage a trois'. | |
| Source | Trends Cell Biol. 4:287-291(1994). | |
| PubMed ID | 14731592 |
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