PROSITE documentation PDOC00789Dehydroquinase class II signature
3-dehydroquinate dehydratase (EC 4.2.1.10), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. Class-II enzymes are homododecameric enzymes of about 17 Kd. They are found in some bacteria such as actinomycetales [1,2] and some fungi where they act in a catabolic pathway that allows the use of quinic acid as a carbon source. As a signature pattern, we selected a conserved region in the N-terminal section.
Last update:December 2004 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Garbe T. Servos S. Hawkins A. Dimitriadis G. Young D. Dougan G. Charles I. |
| Title | The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. | |
| Source | Mol. Gen. Genet. 228:385-392(1991). | |
| PubMed ID | 1910148 |
| 2 | Authors | Lalonde G. O'Hanley P.D. Stocker B.A.D. Denich K.T. |
| Title | Characterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE. | |
| Source | Mol. Microbiol. 11:273-280(1994). | |
| PubMed ID | 8170389 |
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