We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00801Transposases, IS30 family, signature
View entry in original PROSITE document format
View entry in raw text format (no links)
PURL: https://purl.expasy.org/prosite/documentation/PDOC00801
Description
Autonomous mobile genetic elements such as transposon or insertion sequences (IS) encode an enzyme, called transposase, required for excising and inserting the mobile element. On the basis of sequence similarities, transposases can be grouped into various families. One of these families has been shown [1,2] to consist of transposases from the following elements:
- Is30 from Escherichia coli.
- Is1086 from Alcaligenes eutrophus.
- Is1161 from Streptococcus salivarius.
- Is4351 (Tn4551) from Bacteroides fragilis.
These transposases are proteins of 340 to 380 amino acids. The best conserved region is located in their C-terminal section and is used as a signature pattern.
Last update:November 1995 / First entry.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Dong Q. Sadouk A. van der Lelie D. Taghavi S. Ferhat A. Nuyten J.M. Borremans B. Mergeay M. Toussaint A. |
| Title | Cloning and sequencing of IS1086, an Alcaligenes eutrophus insertion element related to IS30 and IS4351. | |
| Source | J. Bacteriol. 174:8133-8138(1992). | |
| PubMed ID | 1334071 |
| 2 | Authors | Giffard P.M. Rathsam C. Kwan E. Kwan D.W.L. Bunny K.L. Koo S.-P. Jacques N.A. |
| Title | The ftf gene encoding the cell-bound fructosyltransferase of Streptococcus salivarius ATCC 25975 is preceded by an insertion sequence and followed by FUR1 and clpP homologues. | |
| Source | J. Gen. Microbiol. 139:913-920(1993). | |
| PubMed ID | 8393068 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.