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PROSITE documentation PDOC00801

Transposases, IS30 family, signature





Description

Autonomous mobile genetic elements such as transposon or insertion sequences (IS) encode an enzyme, called transposase, required for excising and inserting the mobile element. On the basis of sequence similarities, transposases can be grouped into various families. One of these families has been shown [1,2] to consist of transposases from the following elements:

  • Is30 from Escherichia coli.
  • Is1086 from Alcaligenes eutrophus.
  • Is1161 from Streptococcus salivarius.
  • Is4351 (Tn4551) from Bacteroides fragilis.

These transposases are proteins of 340 to 380 amino acids. The best conserved region is located in their C-terminal section and is used as a signature pattern.

Last update:

November 1995 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

TRANSPOSASE_IS30, PS01043; Transposases, IS30 family, signature  (PATTERN)


References

1AuthorsDong Q. Sadouk A. van der Lelie D. Taghavi S. Ferhat A. Nuyten J.M. Borremans B. Mergeay M. Toussaint A.
TitleCloning and sequencing of IS1086, an Alcaligenes eutrophus insertion element related to IS30 and IS4351.
SourceJ. Bacteriol. 174:8133-8138(1992).
PubMed ID1334071

2AuthorsGiffard P.M. Rathsam C. Kwan E. Kwan D.W.L. Bunny K.L. Koo S.-P. Jacques N.A.
TitleThe ftf gene encoding the cell-bound fructosyltransferase of Streptococcus salivarius ATCC 25975 is preceded by an insertion sequence and followed by FUR1 and clpP homologues.
SourceJ. Gen. Microbiol. 139:913-920(1993).
PubMed ID8393068



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