PROSITE documentation PDOC00810SAICAR synthetase signatures
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase) catalyzes the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to SAICAR [1]. In bacteria (gene purC), fungi (gene ADE1) and plants, SAICAR synthetase is a monofunctional protein; in higher vertebrates it is the N-terminal domain of a bifunctional enzyme that also catalyze phosphoribosylaminoimidazole carboxylase (AIRC) activity.
As signature patterns for SAICAR synthetase, we selected two conserved regions in the central section of this enzyme.
Last update:December 2004 / Pattern and text revised.
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| 1 | Authors | Zalkin H. Dixon J.E. |
| Title | De novo purine nucleotide biosynthesis. | |
| Source | Prog. Nucleic Acid Res. Mol. Biol. 42:259-287(1992). | |
| PubMed ID | 1574589 |
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