PROSITE documentation PDOC00820Prokaryotic diacylglycerol kinase signature
Description
Diacylglycerol kinase (EC 2.7.1.107) (DAGK) is an enzyme that catalyzes the formation of phosphatidic acid from diacylglycerol and ATP, an important step in phospholipid biosynthesis. In bacteria DAGK is very small (13 to 15 Kd) membrane protein which seems to contain three transmembrane domains [1].
As a signature for bacterial DAGK, we selected the best conserved region, a stretch of 12 residues which are located in a cytoplasmic loop between the second and third transmembrane domains.
Last update:July 1998 / Pattern and text revised.
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Technical section
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Reference
| 1 | Authors | Smith R.L. O'Toole J.F. Maguire M.E. Sanders C.R. II |
| Title | Membrane topology of Escherichia coli diacylglycerol kinase. | |
| Source | J. Bacteriol. 176:5459-5465(1994). | |
| PubMed ID | 8071224 |
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