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PROSITE documentation PDOC00822

grpE protein signature





Description

In prokaryotes the grpE protein [1] stimulates, jointly with dnaJ, the ATPase activity of the dnaK chaperone. It seems to accelerate the release of ADP from dnaK thus allowing dnaK to recycle more efficiently. GrpE is a protein of about 22 to 25 Kd. In yeast, an evolutionary related mitochondrial protein (gene GRPE) has been shown [2] to associate with the mitochondrial hsp70 protein and to thus play a role in the import of proteins from the cytoplasm.

As a signature pattern, we selected the most conserved region of grpE. It is located in the C-terminal section.

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Expert(s) to contact by email:

Georgopoulos C.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

GRPE, PS01071; grpE protein signature  (PATTERN)


References

1AuthorsGeorgopoulos C. Welch W.J.
TitleRole of the major heat shock proteins as molecular chaperones.
SourceAnnu. Rev. Cell Biol. 9:601-634(1993).
PubMed ID8280473
DOI10.1146/annurev.cb.09.110193.003125

2AuthorsBolliger L. Deloche O. Glick B.S. Georgopoulos C. Jeno P. Kronidou N. Horst M. Morishima N. Schatz G.
TitleA mitochondrial homolog of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viability.
SourceEMBO J. 13:1998-2006(1994).
PubMed ID8168496



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