PROSITE documentation PDOC00845
Casein kinase II regulatory subunit signature


Casein kinase II (CK-2) [1] is an ubiquitous eukaryotic serine/threonine protein kinase which is found both in the cytoplasm and the nucleus and whose substrates are numerous. It generally phosphorylates Ser or Thr at the N-terminal of stretch of acidic residues (see <PDOC00006>). CK-2 exists as an heterotetramer composed of two catalytic subunits (α) and two regulatory subunits (β). In most species there are two closely related isoforms of the catalytic subunit: α and α'. Some species, such as fungi and plants, express two forms of regulatory subunits: β and β'. The β subunit plays a complex role in regulating the basal catalytic activity of the α subunit. The β subunit is a highly conserved protein of about 25 Kd that contains, in its central section, a cysteine-rich motif that could be involved in binding a metal such as zinc [2]. We have used this region as a signature pattern.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CK2_BETA, PS01101; Casein kinase II regulatory subunit signature  (PATTERN)


1AuthorsAllende J.E. Allende C.C.
TitleProtein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation.
SourceFASEB J. 9:313-323(1995).
PubMed ID7896000

2AuthorsReed J.C. Bidwai A.P. Glover C.V.C.
TitleCloning and disruption of CKB2, the gene encoding the 32-kDa regulatory beta'-subunit of Saccharomyces cerevisiae casein kinase II.
SourceJ. Biol. Chem. 269:18192-18200(1994).
PubMed ID8027080

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