PROSITE documentation PDOC00862Translation initiation factor SUI1 profile
Description
In budding yeast (Saccharomyces cerevisiae), SUI1 is a translation initiation factor that functions in concert with eIF-2 and the initiator tRNA-Met in directing the ribosome to the proper start site of translation [1]. SUI1 is a protein of 108 residues. Close homologs of SUI1 have been found [2] in mammals, insects and plants.
SUI1 is also evolutionary related to:
- Hypothetical proteins from bacteria such as Escherichia coli (yciH) or Haemophilus influenzae (HI1225).
- Hypothetical proteins from archaea such as Methanococcus jannaschii (MJ0463).
Two eukaryotic proteins also seem to contain a C-terminal SUI1-like domain. These are:
- Density-regulated protein (gene: DENR). This protein is found in mammals, insects, nematodes, plants and fungi.
- Ligatin (gene: LGTN). This protein is found in mammals and insects.
The profile we developed covers the entire C-terminal SUI1-like domain.
Last update:August 2003 / Pattern removed.
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Technical section
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References
| 1 | Authors | Yoon H.J. Donahue T.F. |
| Title | The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon. | |
| Source | Mol. Cell. Biol. 12:248-260(1992). | |
| PubMed ID | 1729602 |
| 2 | Authors | Fields C.A. Adams M.D. |
| Title | Expressed sequence tags identify a human isolog of the suil translation initiation factor. | |
| Source | Biochem. Biophys. Res. Commun. 198:288-291(1994). | |
| PubMed ID | 7904817 |
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