We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00862Translation initiation factor SUI1 profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00862
Description
In budding yeast (Saccharomyces cerevisiae), SUI1 is a translation initiation factor that functions in concert with eIF-2 and the initiator tRNA-Met in directing the ribosome to the proper start site of translation [1]. SUI1 is a protein of 108 residues. Close homologs of SUI1 have been found [2] in mammals, insects and plants.
SUI1 is also evolutionary related to:
- Hypothetical proteins from bacteria such as Escherichia coli (yciH) or Haemophilus influenzae (HI1225).
- Hypothetical proteins from archaea such as Methanococcus jannaschii (MJ0463).
Two eukaryotic proteins also seem to contain a C-terminal SUI1-like domain. These are:
- Density-regulated protein (gene: DENR). This protein is found in mammals, insects, nematodes, plants and fungi.
- Ligatin (gene: LGTN). This protein is found in mammals and insects.
The profile we developed covers the entire C-terminal SUI1-like domain.
Last update:August 2003 / Pattern removed.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Yoon H.J. Donahue T.F. |
| Title | The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon. | |
| Source | Mol. Cell. Biol. 12:248-260(1992). | |
| PubMed ID | 1729602 |
| 2 | Authors | Fields C.A. Adams M.D. |
| Title | Expressed sequence tags identify a human isolog of the suil translation initiation factor. | |
| Source | Biochem. Biophys. Res. Commun. 198:288-291(1994). | |
| PubMed ID | 7904817 |
Copyright
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