We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00887Hypothetical hesB/yadR/yfhF family signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00887
Description
The following uncharacterized proteins have been shown [1] to share regions of similarities:
- Anabaena and related cyanobacteria protein hesB which may be required for nitrogen fixation.
- Escherichia coli hypothetical protein yadR and HI1723, the corresponding Haemophilus influenzae protein.
- Escherichia coli hypothetical protein ydiC.
- Escherichia coli hypothetical protein yfhF and HI0376, the corresponding Haemophilus influenzae protein.
- Mycobacterium tuberculosis hypothetical protein Rv2204c.
- Synechocystis strain PCC 6803 hypothetical protein slr1417.
- Synechocystis strain PCC 6803 hypothetical protein slr1565.
- A hypothetical protein in the nifU 5'region of many nitrogen fixing bacteria.
- Porphyra purpurea chloroplast hypothetical protein in apcF-rps4 intergenic region.
- Yeast hypothetical protein YLL027W.
- Yeast hypothetical protein YPR067W.
These are small proteins (106 to 135 amino-acid residues in bacteria, about 200 residues in fungi) that contain a number of conserved regions. The most noteworthy of these regions is located in the C-terminal extremity, it contains two conserved cysteines. We have used this region as a signature pattern.
Last update:April 2006 / Pattern revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Bairoch A. Rudd K.E. |
| Source | Unpublished observations (1995). |
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