PROSITE documentation PDOC00887
Hypothetical hesB/yadR/yfhF family signature


The following uncharacterized proteins have been shown [1] to share regions of similarities:

  • Anabaena and related cyanobacteria protein hesB which may be required for nitrogen fixation.
  • Escherichia coli hypothetical protein yadR and HI1723, the corresponding Haemophilus influenzae protein.
  • Escherichia coli hypothetical protein ydiC.
  • Escherichia coli hypothetical protein yfhF and HI0376, the corresponding Haemophilus influenzae protein.
  • Mycobacterium tuberculosis hypothetical protein Rv2204c.
  • Synechocystis strain PCC 6803 hypothetical protein slr1417.
  • Synechocystis strain PCC 6803 hypothetical protein slr1565.
  • A hypothetical protein in the nifU 5'region of many nitrogen fixing bacteria.
  • Porphyra purpurea chloroplast hypothetical protein in apcF-rps4 intergenic region.
  • Yeast hypothetical protein YLL027W.
  • Yeast hypothetical protein YPR067W.

These are small proteins (106 to 135 amino-acid residues in bacteria, about 200 residues in fungi) that contain a number of conserved regions. The most noteworthy of these regions is located in the C-terminal extremity, it contains two conserved cysteines. We have used this region as a signature pattern.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HESB, PS01152; Hypothetical hesB/yadR/yfhF family signature  (PATTERN)


1AuthorsBairoch A. Rudd K.E.
SourceUnpublished observations (1995).

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)