PROSITE documentation PDOC00911
ubiE/COQ5 methyltransferase family signatures


The following methyltransferases have been shown [1] to share regions of similarities:

  • Escherichia coli ubiE, which is involved in both ubiquinone and menaquinone biosynthesis and which catalyzes the S-adenosylmethionine dependent methylation of 2-polyprenyl-6-methoxy-1,4-benzoquinol into 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol and of demethylmenaquinol into menaquinol.
  • Yeast COQ5, a ubiquinone biosynthesis methlytransferase.
  • Bacillus subtilis spore germination protein C2 (gene: gercB or gerC2), a probable menaquinone biosynthesis methlytransferase.
  • Lactococcus lactis gerC2 homolog.
  • Caenorhabditis elegans hypothetical protein ZK652.9.
  • Leishmania donovani amastigote-specific protein A41.

These are hydrophilic proteins of about 30 Kd (except for ZK652.9 which is 65 Kd). They can be picked up in the database by the following patterns.

Last update:

December 2004 / Patterns and text revised.


Technical section

PROSITE methods (with tools and information) covered by this documentation:

UBIE_1, PS01183; ubiE/COQ5 methyltransferase family signature 1  (PATTERN)

UBIE_2, PS01184; ubiE/COQ5 methyltransferase family signature 2  (PATTERN)


1AuthorsLee P.T. Hsu A.Y. Ha H.T. Clarke C.F.
TitleA C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene.
SourceJ. Bacteriol. 179:1748-1754(1997).
PubMed ID9045837

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