We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00914ELO family signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00914
Description
The ELO family consist of eukaryotic integral membrane proteins involved in fatty acid elongation. This family consist of:
- Mammalian proteins ELOVL1 to ELOVL4 [1]. These proteins all seem to be involved in the synthesis of very long chain fatty acids.
- Yeast ELO1, ELO2 and ELO3 [2]. They seem to be components of membrane-bound fatty acid elongation systems.
- Caenorhabditis elegans hypothetical protein C40H1.4.
- Caenorhabditis elegans hypothetical protein D2024.3.
The proteins have from 271 to 435 amino acid residues. Structurally, they seem to be formed of three sections: a N-terminal region with two transmembrane domains, a central hydrophilic loop and a C-terminal region that contains from one to three transmembrane domains. As a signature pattern we selected a conserved region that contains three histidines. This region is located in the hydrophilic loop.
Last update:January 2002 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Tvrdik P. Westerberg R. Silve S. Asadi A. Jakobsson A. Cannon B. Loison G. Jacobsson A. |
| Title | Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. | |
| Source | J. Cell Biol. 149:707-718(2000). | |
| PubMed ID | 10791983 |
| 2 | Authors | Oh C.-S. Toke D.A. Mandala S. Martin C.E. |
| Title | ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. | |
| Source | J. Biol. Chem. 272:17376-17384(1997). | |
| PubMed ID | 9211877 |
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