PROSITE documentation PDOC00914ELO family signature
Description
The ELO family consist of eukaryotic integral membrane proteins involved in fatty acid elongation. This family consist of:
- Mammalian proteins ELOVL1 to ELOVL4 [1]. These proteins all seem to be involved in the synthesis of very long chain fatty acids.
- Yeast ELO1, ELO2 and ELO3 [2]. They seem to be components of membrane-bound fatty acid elongation systems.
- Caenorhabditis elegans hypothetical protein C40H1.4.
- Caenorhabditis elegans hypothetical protein D2024.3.
The proteins have from 271 to 435 amino acid residues. Structurally, they seem to be formed of three sections: a N-terminal region with two transmembrane domains, a central hydrophilic loop and a C-terminal region that contains from one to three transmembrane domains. As a signature pattern we selected a conserved region that contains three histidines. This region is located in the hydrophilic loop.
Last update:January 2002 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Tvrdik P. Westerberg R. Silve S. Asadi A. Jakobsson A. Cannon B. Loison G. Jacobsson A. |
| Title | Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. | |
| Source | J. Cell Biol. 149:707-718(2000). | |
| PubMed ID | 10791983 |
| 2 | Authors | Oh C.-S. Toke D.A. Mandala S. Martin C.E. |
| Title | ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. | |
| Source | J. Biol. Chem. 272:17376-17384(1997). | |
| PubMed ID | 9211877 |
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