PROSITE documentation PDOC00925Iodothyronine deiodinases active site
Iodothyronine deiodinase (EC 1.97.1.10) (DI) [1,2] is the vertebrate enzyme responsible for the deiodination of the prohormone thyroxine (T4 or 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine) and of T3 into the inactive metabolite T2 (3,3'-diiodothyronine). Three types of DI are known. All known DI are proteins of about 250 residues that contain a selenocysteine at their active site.
As a signature pattern we selected the best conserved region, it is located in the central part of the enzyme and contains the active site selenocysteine.
Last update:January 2008 / Pattern updated.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | St Germain D.L. |
| Source | (In) Thyroid hormone metabolism: molecular biology and alternative pathways, Wu S.Y., Visser T.J., Eds., pp45-66, CRC Press, Ann Arbor, (1994). |
| 2 | Authors | Davey J.C. Becker K.B. Schneider M.J. St Germain D.L. Galton V.A. |
| Title | Cloning of a cDNA for the type II iodothyronine deiodinase. | |
| Source | J. Biol. Chem. 270:26786-26789(1995). | |
| PubMed ID | 7592917 |
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