|PROSITE documentation PDOC00941|
N-acetyl-γ-glutamyl-phosphate reductase (EC 220.127.116.11) (AGPR) [1,2] is the enzyme that catalyzes the third step in the biosynthesis of arginine from glutamate, the NADP-dependent reduction of N-acetyl-5-glutamyl phosphate into N-acetylglutamate 5-semialdehyde.
In bacteria it is a monofunctional protein of 35 to 38 Kd (gene argC) while in fungi it is part of a bifunctional mitochondrial enzyme (gene ARG5,6, arg11 or arg-6) which contains a N-terminal acetylglutamate kinase (EC 18.104.22.168) domain and a C-terminal AGPR domain.
In the Escherichia coli enzyme, a cysteine has been shown to be implicated in the catalytic activity, the region around this residue is well conserved and can be used as a signature pattern.Last update:
April 2006 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Ludovice M. Martin J.F. Carrachas P. Liras P.|
|Title||Characterization of the Streptomyces clavuligerus argC gene encoding N-acetylglutamyl-phosphate reductase: expression in Streptomyces lividans and effect on clavulanic acid production.|
|Source||J. Bacteriol. 174:4606-4613(1992).|
|2||Authors||Gessert S.F. Kim J.H. Nargang F.E. Weiss R.L.|
|Title||A polyprotein precursor of two mitochondrial enzymes in Neurospora crassa. Gene structure and precursor processing.|
|Source||J. Biol. Chem. 269:8189-8203(1994).|