PROSITE documentation PDOC00947Urocanase signature
Urocanase [1] (EC 4.2.1.49) (also known as imidazolonepropionate hydrolase or urocanate hydratase) is the enzyme that catalyzes the second step in the degradation of histidine, the hydration of urocanate into imidazolonepropionate. Urocanase is found in some bacteria (gene hutU), in the liver of many vertebrates and has also been found in the plant Trifolium repens (white clover).
Urocanase is a protein of about 60 Kd, it binds tightly to NAD(+) and uses it as an electrophil cofactor. We have developed a signature pattern based on a conserved region in the C-terminal part of the enzyme.
Last update:August 2002 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Retey J. |
| Title | The urocanase story: a novel role of NAD+ as electrophile. | |
| Source | Arch. Biochem. Biophys. 314:1-16(1994). | |
| PubMed ID | 7944380 |
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