PROSITE documentation PDOC00963
Arthropod CHH/MIH/GIH neurohormones family signature


Arthropod express a family of neuropeptides [1] which so far consist of the following types of neurohormones:

  • Crustacean hyperglycemic hormone (CHH). CHH is primarily involved in blood sugar regulation, but also plays a role in the control of molting and reproduction.
  • Molt-inhibiting hormone (MIH). MIH inhibits Y-organs where molting hormone (ecdysteroid) is secreted. A molting cycle is initiated when MIH secretion diminishes or stops.
  • Gonad-inhibiting hormone (GIH), also known as vitellogenesis-inhibiting hormone (VIH) because of its role in inhibiting vitellogenesis in female animals.
  • Mandibular organ-inhibiting hormone (MOIH). MOIH represses the synthesis of methyl farnesoate, the precursor of insect juvenile hormone III in the mandibular organ.
  • Ion transport peptide (ITP) from locust. ITP stimulates salt and water reabsorption and inhibits acid secretion in the ileum of the locust.
  • Caenorhabditis elegans hypothetical protein ZC168.2.

These neurohormones are peptides of 70 to 80 residues which are processed from larger size precursors. They contain six conserved cysteines that are involved in disulfide bonds, as shown in the following schematic representation.

                          |               |
          |                  |          ******|*********
          +------------------|----------------+        |
                             |                         |
'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.
Last update:

May 2004 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CHH_MIH_GIH, PS01250; Arthropod CHH/MIH/GIH neurohormones family signature  (PATTERN)


1AuthorsDe Kleijn D.P.V. Van Herp F.
TitleMolecular biology of neurohormone precursors in the eyestalk of Crustacea.
SourceComp. Biochem. Physiol. 112B:573-579(1995).

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