PROSITE documentation PDOC00973
Tpx family signature


Escherichia coli protein tpx [1] is an antioxidant protein with a thiol peroxidase activity. It is a small protein of 18 Kd whose sequence is well conserved in other bacterial species.

As a signature pattern we selected the best conserved region which is located in the central part of these proteins. This region contains one of two conserved cysteines.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

TPX, PS01265; Tpx family signature  (PATTERN)


1AuthorsCha M.-K. Kim H.-K. Kim I.-H.
TitleThioredoxin-linked 'thiol peroxidase' from periplasmic space of Escherichia coli.
SourceJ. Biol. Chem. 270:28635-28641(1995).
PubMed ID7499381

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