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PROSITE documentation PDOC00977 |
Mammalian band 7 protein [1] (also known as 7.2B or stomatin) is an integral membrane phosphoprotein of red blood cells thought to regulate cation conductance by interacting with other proteins of the junctional complex of the membrane skeleton. Structurally, band 7 is evolutionary related to the following proteins:
Structurally all these proteins consist of a short N-terminal domain which is followed by a transmembrane region and a variable size (from 170 to 350 residues) C-terminal domain.
As a signature pattern, we selected a conserved region located about 110 residues after the transmembrane domain.
Last update:December 2001 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Gallagher P.G. Forget B.G. |
Title | Structure, organization, and expression of the human band 7.2b gene, a candidate gene for hereditary hydrocytosis. | |
Source | J. Biol. Chem. 270:26358-26363(1995). | |
PubMed ID | 7592848 |
2 | Authors | Huang M. Gu G. Ferguson E.L. Chalfie M. A stomatin-like protein necessary for mechanosensation in C. |
Title | elegans. | |
Source | Nature 378:292-295(1995). | |
PubMed ID | 7477350 |