Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00978Sodium:sulfate symporter family signature
View entry in original PROSITE document format
View entry in raw text format (no links)
PURL: https://purl.expasy.org/prosite/documentation/PDOC00978
Integral membrane proteins that mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. One of these families currently consists of the following proteins:
- Mammalian sodium/sulfate cotransporter [1].
- Mammalian renal sodium/dicarboxylate cotransporter [2], which transports succinate and citrate.
- Mammalian intestinal sodium/dicarboxylate cotransporter.
- Chlamydomonas reinhardtii putative sulfur deprivation response regulator SAC1 [3].
- Caenorhabditis elegans hypothetical proteins B0285.6, F31F6.6, K08E5.2 and R107.1.
- Escherichia coli hypothetical protein yfbS.
- Haemophilus influenzae hypothetical protein HI0608.
- Synechocystis strain PCC 6803 hypothetical protein sll0640.
- Methanococcus jannaschii hypothetical protein MJ0672.
These transporters are proteins of from 430 to 620 amino acids which are highly hydrophobic and which probably contain about 12 transmembrane regions. As a signature pattern, we selected a conserved region which is located in or near the penultimate transmembrane region.
Last update:December 2004 / Pattern and text revised.
-------------------------------------------------------------------------------
PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Markovich D. Forgo J. Stange G. Biber J. Murer H. |
| Title | Expression cloning of rat renal Na+/SO4(2-) cotransport. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 90:8073-8077(1993). | |
| PubMed ID | 7690140 |
| 2 | Authors | Pajor A.M. |
| Source | Am. J. Physiol. 270:642-648(1996). |
| 3 | Authors | Davies J.P. Yildiz F.H. Grossman A. |
| Title | Sac1, a putative regulator that is critical for survival of Chlamydomonas reinhardtii during sulfur deprivation. | |
| Source | EMBO J. 15:2150-2159(1996). | |
| PubMed ID | 8641280 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.