PROSITE documentation PDOC00978
Sodium:sulfate symporter family signature


Integral membrane proteins that mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities into a number of distinct families. One of these families currently consists of the following proteins:

  • Mammalian sodium/sulfate cotransporter [1].
  • Mammalian renal sodium/dicarboxylate cotransporter [2], which transports succinate and citrate.
  • Mammalian intestinal sodium/dicarboxylate cotransporter.
  • Chlamydomonas reinhardtii putative sulfur deprivation response regulator SAC1 [3].
  • Caenorhabditis elegans hypothetical proteins B0285.6, F31F6.6, K08E5.2 and R107.1.
  • Escherichia coli hypothetical protein yfbS.
  • Haemophilus influenzae hypothetical protein HI0608.
  • Synechocystis strain PCC 6803 hypothetical protein sll0640.
  • Methanococcus jannaschii hypothetical protein MJ0672.

These transporters are proteins of from 430 to 620 amino acids which are highly hydrophobic and which probably contain about 12 transmembrane regions. As a signature pattern, we selected a conserved region which is located in or near the penultimate transmembrane region.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

NA_SULFATE, PS01271; Sodium:sulfate symporter family signature  (PATTERN)


1AuthorsMarkovich D. Forgo J. Stange G. Biber J. Murer H.
TitleExpression cloning of rat renal Na+/SO4(2-) cotransport.
SourceProc. Natl. Acad. Sci. U.S.A. 90:8073-8077(1993).
PubMed ID7690140

2AuthorsPajor A.M.
SourceAm. J. Physiol. 270:642-648(1996).

3AuthorsDavies J.P. Yildiz F.H. Grossman A.
TitleSac1, a putative regulator that is critical for survival of Chlamydomonas reinhardtii during sulfur deprivation.
SourceEMBO J. 15:2150-2159(1996).
PubMed ID8641280

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